BIGG

New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice

Lindner, Andreas K; Lejon, Veerle; Chappuis, François; Seixas, Jorge; Kazumba, Leon; Barrett, Michael P; Mwamba, Erick; Erphas, Olema; Akl, Elie A; Villanueva, Gemma; Bergman, Hanna; Simarro, Pere; Ebeja, Augustin Kadima; Priotto, Gerardo; Franco, Jose Ramon.

Lancet infect. dis; 20 (2), 2020

Human African trypanosomiasis caused by Trypanosoma brucei gambiense is a parasitic infection that usually progresses to coma and death unless treated. WHO has updated its guidelines for the treatment of this infection on the basis of independent literature reviews and using the Grading of Recommendation...

Tripanosomiasis Africana/tratamiento farmacológico, Trypanosoma brucei gambiense, Pentamidina/administración & dosificación, Nifurtimox/administración & dosificación, Nitroimidazoles/administración & dosificación, Líquido Cefalorraquídeo/parasitología, Quimioterapia Combinada, Tripanocidas/administración & dosificación, Eflornitina/administración & dosificación, Tripanosomiasis Africana/parasitología

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American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support

Red cell transfusions remain a mainstay of therapy for patients with sickle cell disease (SCD), but pose significant clinical challenges. Guidance for specific indications and administration of transfusion, as well as screening, prevention, and management of alloimmunization, delayed hemolytic transfusio...